SSRIs: What You Should Know About These Antidepressants

By on July 24, 2013
ssri side effects

Many common ejaculation delaying products that are available on the market these days have selective serotonin re-uptake inhibitors as part of their chemical make-up. Selective serotonin re-uptake inhibitors, or SSRIs, are compounds that can be used to delay a man’s climax.

How do they work?

When a man orgasms, their brain releases an extra jolt of serotonin into their system. If you’ve ever felt happy, content, or euphoric after sex, it’s because of all the serotonin floating around in your system. Taking SSRIs basically prevents your brain from registering the serotonin in your system, which prevents you from achieving an orgasm.

What are the common SSRIs used?

While there are many types of SSRIs on the market, there are only a few which are used to treat premature ejaculation, such as:

  • Dapoxetine is a short-acting SSRI that is the only drug with FDA-approval on the market which is used to treat premature ejaculation. It is also approved in several European countries, such as Sweden, Finland, Austria, Portugal, and Germany. At present, however, Dapoxetine is still waiting approval for commercial release in the U.S. It has already finished Phase III in the drug trials, which included participants from 25 countries including the U.S. The tests showed that the recipients generally had a good response to the drug.
  • Paroxetine is a drug treatment which shows to have the most promise when it comes to controlling premature ejaculation in men, however, since it is still in testing phase, it still does not have FDA-approval.
  • Tramadol is an FDA-approved oral analgesic used to treat mild pain, but has been found to be effective in treating premature ejaculation. Tramadol has been found to increase ejaculatory latency by up to 4-20 times almost 100% of men tested.
  • Clomipramine is a drug that is sometimes prescribed to treat PE, because the drug has been found to delay the ejaculatory response. According to the Mayo clinic, the drug has also been found to increase sexual desire and gratification after the act.

How do SSRIs help with premature ejaculation?

Men who experience premature ejaculation have been found to be especially sensitive to the amount of serotonin in their system, making it faster and easier for them to achieve orgasm. The presence of SSRIs in the system prolongs the sexual experience for the man, making his system less sensitive to serotonin.

According to a study published in the International Journal of Urology, it was found that using SSRIs with Viagra gives the best results in helping delay the ejaculatory response in men. It was also found to increase sexual satisfaction.

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What side effects SSRIs have?

As with most drugs, there are side effects that one will experience when taking SSRIs. Generally, it is during the first four weeks where you will feel most of the side effects. One of the downsides of taking SSRIs is that they are slow to take effect (around 6-8 weeks) before they can reach their full potential. Some of the general side effects include:

  • Headaches
  • Dizziness/Nausea
  • Vomiting
  • Strange dreams
  • Insomnia/Changes in sleep pattern
  • Diarrhea
  • Weight loss/gain (-/+ 7 pounds)
  • 1.7% increased risk of bone fracture
  • Mania
  • Tremors
  • Anxiety
  • Depression
  • Photosensitivity

Ironically, one of the most common side effects of using SSRIs are post-SSRI sexual dysfunction disorders such as diminished libido and erectile dysfunction, especially during the first four weeks of taking the SSRI.

The FDA has given many SSRIs a black-box warning – the most serious FDA label alert – because it has been found that they can increase the risk of suicidal tendencies and behavior in men with depression or psychological disorders.

There are several more serious (but rarer) side effects from taking SSRIs, such as:

  • Suicidal thoughts
  • Low Sodium

Men who are taking diuretics should take care when they take SSRIs at the same time. Those who suffer from low sodium may experience headaches, memory impairment, difficulty in concentration, and weakness.

  • Abdominal Bleeding

Men who are taking blood thinners or non-steroidal anti-inflammatory drugs such as ibuprofen or aspirin can experience abdominal bleeding when SSRIs are taken in conjunction with these medicines.

  • Prolonged Erection

While it may sound like a good idea, a prolonged erection can be painful at the very least, and may cause harm to both nerves and muscles if left untreated.


Before you take any SSRIs to help with your premature ejaculation, you should consult with your sexual health provider to know whether you are at risk when you take SSRIs. You should be honest with your family health history, as well as with any medications that you are taking or any existing medical conditions that you may have so that your physician will be able to prescribe the right SSRI for you.




Wang WF, Wang Y, Minhas S, Ralph DJ (April 2007). “Can sildenafil treat primary premature ejaculation? A prospective clinical study”. International Journal of Urology 14 (4): 331–5. doi:10.1111/j.1442-2042.2007.01606.x 17470165.

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