Para-aminobenzoic acid to treat Peyronie’s disease
Peyronie’s disease is a condition in which a hardened piece of scar tissue forms on one side of the penis. If the plaque becomes large enough, it reduces flexibility of the penis. During erection, the less-flexible part of the penis expands to a lesser extent, causing the penis to bend. Pain may occur as well. Severe curvature of the penis can make intercourse difficult or even impossible.
Para-aminobenzoic acid or its shorter version PABA, has been suggested for a variety of diseases in which abnormal fibrous tissue is involved, like Peyronie’s disease. PABA is reported to have an anti-fibrotic (anti-scar) effect in the body, and for this reason it is used to treat certain skin conditions in which fibrosis, inelasticity or thickening of the skin occurs, this why it is thought that PABA can improve Peyronie’s condition.
Some recommend adding PABA to the treatment plan because there is good science to support its use in the crooked penis condition. PABA research is also good not only for Peyronie’s disease, but for other conditions that have similar tissue fibrosis components, such as scleroderma. While most of the research done on Peyronie’s treatment has been conducted with potassium para-aminobenzoate (POTABA), this particular form of PABA frequently causes severe gastric distress, and for this reason it is a prescription medication. The more safe and less expensive PABA can be readily gotten without a prescription, and hence it is less expensive without sacrificing effectiveness of treatment.